Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Digital Module 05: Diagnostic Measurement—The G‐DINA Framework https://ncme.elevate.commpartners.com     

Wenchao Ma  Jimmy de la Torre 《Educational Measurement》2019,38(2):114-115

In this ITEMS module, we introduce the generalized deterministic inputs, noisy “and” gate (G‐DINA) model, which is a general framework for specifying, estimating, and evaluating a wide variety of cognitive diagnosis models. The module contains a nontechnical introduction to diagnostic measurement, an introductory overview of the G‐DINA model, as well as common special cases, and a review of model‐data fit evaluation practices within this framework. We use the flexible GDINA R package, which is available for free within the R environment and provides a user‐friendly graphical interface in addition to the code‐driven layer. The digital module also contains videos of worked examples, solutions to data activity questions, curated resources, a glossary, and quizzes with diagnostic feedback.  相似文献   

银杏叶提取物对大鼠血液CK、LDH、IL-4活性的影响   总被引：3，自引：0，他引：3  

牛英鹏 《北京体育大学学报》2006,29(10):1370-1372

为探讨银杏叶提取物对大鼠抗疲劳能力的影响,将86只SD大鼠随机分为对照组和服药组,通过适应性训练后,进行一次力竭性运动,测定运动后即刻、运动后24h、48 h的血液CK、LDH和IL-4等有关指标.结果表明:与对照组相比,服药组的各指标升高幅度均较低(p＜0.01).结论:银杏叶提取物对骨骼肌细胞膜的正常结构和机能具有保护作用,能降低运动后急性免疫应答反应,因而具有抗运动性疲劳的作用,将其开发为运动营养补剂应具广阔的前景.  相似文献   

纳米——ZnFe_2O_4/SiO_2上环己烷催化氧化反应的影响因素     

李纪连 《大连教育学院学报》2001,17(4):54-55

介绍了用纳米———ZnFe2 O4/SiO2 半导体材料作光催化剂 ,用分子氧催化氧化环己烷的实验 ,根据目前所建立的半导体粒子光催化反应机理的模式 ,探讨了其反应机理 ,并进一步研究了水分子以及电子或空穴捕获剂对该反应的影响。  相似文献   

国内外1975～1991年间关于中小企业信息管理的研究成果统计分析及建议     

冷伏海  冯路 《中国图书馆学报》2002,28(1)

对 1975～ 1991年间国内外有关中小企业研究的文章从关键词分布、主题分布、国家分布等方面进行了统计 ,具体分析了文章主题的内容 ,进而指出我国在这些方面亟待解决与完善的问题 ,对我国支撑中小企业的信息管理提出参考性建议。表 4 ,参考文献 8。  相似文献   

关于世界地区表“198古代地区”的探讨——与冯倍青同志商榷     

肖燕 《图书馆论坛》2008,28(1):92-95

通过分析古代地区表下各古代国家的历史,研究<中图法>(四版)类目划分的基本原则与修订重点,分析了"198古代地区"立类的合理性,并建议在198各下级类目增加类目注释,并修改类目注释示例.  相似文献   

The Impact of Museum Purchase on the Auction Prices of Paintings   总被引：1，自引：1，他引：0  

Werner W. Pommerehne  Lars P. Feld 《Journal of Cultural Economics》1997,21(3):249-271

This study examines how art museumspurchasing policy influences the auction prices ofpaintings. Using a cross section of non-speculativetransactions during the period 1820–1970, we findconsiderable empirical support for the hypothesisthat public museums outside the U.S. pay above averageprices in auction markets providing higher thanaverage yields to private sellers. The typical U.S.private museums appear to be more restricted byfinancial constraints and the development of thegeneral economic conditions than their publiccounterparts.  相似文献   

《中图法》"多重列类"探微     

宋力 《图书馆建设》2006,(5):66-68

对《中图法》(第4版)中的多重列类的特点、表现形式、作用、类型及其存在的问题进行了探讨。  相似文献   

对民国档案文件级整理工作的思索     

陈晓敏 《山西档案》2006,(1):35-37

在建国后五十多年时间里，档案工作在民国档案整理工作中，遵循档案形成的客观规律，依据全宗原则、利用原基础原则，对全国民国档案进行了案卷级整理工作，逐步建立了包括全宗目录、案卷目录、人名目录、地名目录等在内的民国档案目录体系，部分档案馆还建立了馆藏民国档案案卷级机读目录数据库。不过，随着民国档案开放力度增大，对档案内容信息的揭示提出了更高的要求，原有的民国档案整理成果已难满足现有的民国档案工作需要，对民国档案信息作进一步开发，即开展民国档案件级整理工作已逐渐被提上议事日程，但这项工作对我们来说是崭新的，我们需要对其必要性、和案卷级整理工作的衔接、应结合档案馆数字化工作开展以及在整理人员启用上如何谋求社会力量的支援等等问题加以认真思索。  相似文献   

论信息伦理的四维架构   总被引：6，自引：0，他引：6  

沙勇忠 《情报学报》2004,23(4):484-489

本文提出了由要素维、领域维、层次维和利害关系人维构成的信息伦理的四维架构理论。四个维度各有理论上需要研究和解决的问题 ,并从整体上标示出信息伦理领域的主要知识范畴。四维架构理论也为具体的信息伦理分析提供了一个理论框架  相似文献